2024 03 209-218
肺癌内科治疗临床研究十年回顾和现状
基金项目(Foundation):
邮箱(Email):
DOI:
10.13267/j.cnki.syzlzz.2024.033
中文作者单位:
同济大学附属上海市肺科医院肿瘤科, 上海 200433;同济大学附属东方医院肿瘤科, 上海 200123
摘要(Abstract):
肺癌作为全球死亡率最高的恶性肿瘤，严重威胁人类健康。近10年来，随着精准医学时代的到来，肺癌治疗格局已发生翻天覆地的变化。多项围术期免疫或靶向治疗相关的临床研究的公布让更多早期非小细胞肺癌（non-small-cell lung cancer，NSCLC）患者有望实现肿瘤“治愈”。此外，免疫治疗及靶向治疗也让更多晚期NSCLC患者有望实现“慢病化”。多种新型药物的研发，如抗体-药物偶联物（antibody-drug conjugate，ADC）、免疫双抗及肿瘤疫苗等百花齐放，进一步提高了抗肿瘤治疗疗效。本文将对近10年肺癌内科治疗领域的重要研究进行回顾，并根据目前治疗现状探讨未来发展方向。
关键词(KeyWords):
肺癌;靶向治疗;免疫治疗
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参考文献
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[26] Zhou C, Wu YL, Chen G, et al. Final overall survival results from a randomised, phase Ⅲ study of erlotinib versus chemotherapy as first-line treatment of EGFR mutation-positive advanced non-small-cell lung cancer (OPTIMAL, CTONG-0802)[J]. Ann Oncol, 2015, 26(9): 1877-1883.
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[32] Shi YK, Chen GY, Wang X, et al. Furmonertinib (AST2818) versus gefitinib as first-line therapy for Chinese patients with locally advanced or metastatic EGFR mutation-positive non-small-cell lung cancer (FURLONG): a multicentre, double-blind, randomised phase 3 study[J]. Lancet Respir Med, 2022, 10(11): 1019-1028.
[33] Lu S, Dong XR, Jian H, et al. AENEAS: a randomized phase Ⅲ trial of aumolertinib versus gefitinib as first-line therapy for locally advanced or metastatic non-small-cell lung cancer with EGFR exon 19 deletion or L858R mutations[J]. J Clin Oncol, 2022, 40(27): 3162-3171.
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基本信息:
DOI：10.13267/j.cnki.syzlzz.2024.033
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引用信息:
[1]陈薪如1,周彩存2.肺癌内科治疗临床研究十年回顾和现状[J],2024,39(03):209-218.DOI:10.13267/j.cnki.syzlzz.2024.033.
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