2013 05 v.28 550-552
MAPK信号传导通路与肿瘤的发生
基金项目(Foundation):
国家自然科学基金(81072244)
邮箱(Email):
DOI:
10.13267/j.cnki.syzlzz.2013.05.028
中文作者单位:
中国医科大学;
摘要(Abstract):
肿瘤的发生是多因素、多机制参与的结果,涉及到一系列信号传导分子的改变。其中丝裂原活化蛋白激酶(MAPK)信号传导通路与肿瘤的发生密切相关。MAPK信号传导通路是复杂的网络系统,在细胞增殖、凋亡、侵袭、转移以及血管形成的过程中发挥着重要的作用。
关键词(KeyWords):
肿瘤;;MAPK信号通路;;细胞凋亡;;肿瘤转移;;肿瘤侵润;;血管生成因子
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参考文献
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[25]Liu H,Wang Z,Li Y,et al.Simvastatin prevents proliferation and bone metastases of lung adenocarcinoma in vitro and in vivo[J].Neoplasma,2013,60(3):240-246.
[26]Deng W,Sui H,Wang Q,et al.A Chinese herbal formula,Yi-Qi-Fu-Sheng,inhibits migration/invasion of colorectal cancer by down-regulating MMP-2/9 via inhibiting the activation of ERK/MAPK signaling pathways[J].BMC Complement Altern Med,2013,13(1):65.
[27]万芳,钟刚,何福仙,等.ERK/MAPK信号通路激活与乳腺癌细胞浸润性生长的关系[J].医学研究生报,2004,17(6):490-492.
[28]Drigotas M,Affolter A,Mann WJ,et al.Reactive oxygen species activation of MAPK pathway results in VEGF upregulation as an undesired irradiation response[J].J Oral Pathol Med,2013 Mar 11.doi:10.1111/jop.12056.
[29]Tate CM,Blosser W,Wyss L,et al.LY2228820dimesylate,a selective inhibitor of p38 mitogen-activated protein kinase,reduces angiogenic endothelial cord formation in vitro and in vivo[J].J Biol Chem,2013,288(9):6743-6753.
[30]Lee SH,Lee J,Jung MH,et al.Glyceollins,a novel class of soy phytoalexins,inhibit angiogenesis by blocking the VEGF and bFGF signaling pathways[J].Mol Nutr Food Res,2013,57(2):225-234.
[31]Culig Z.Interleukin-6 as a therapy target in oral squamous carcinoma[J].Expert Opin Ther Targets,2013,17(1):53-59.
[2]韦淑琴,隋丽华,魏丽惠.丝裂原活化蛋白激酶通路在妇科肿瘤中的研究进展[J].国外医学妇产科学分册,2004,31(1):51-53.
[3]魏小勇,黎才海,饶荣生.p38 MAPK信号通路与肿瘤的关系[J].实用癌症杂志,2009,24(1):101-103.
[4]郝玉琴,郑绘霞.MAPK/ERK信号传导通路在肿瘤治疗中作用机制的研究[J].中国麻风病皮肤杂志,2012,28(7):490-493.
[5]Sadaria MR,Yu JA,Meng X,et al.Secretory phospholipase A2 mediates human esophageal adenocarcinoma cell growth and proliferation via ERK 1/2pathway[J].Anticancer Res,2013,33(4):1337-1342.
[6]Walters DM,Lindberg JM,Adair SJ,et al.Inhibition of the growth of patient-derived pancreatic cancer xenografts with the MEK inhibitor trametinib is augmented by combined treatment with the epidermal growth factor receptor/HER2 inhibitor lapatinib[J].Neoplasia,2013,15(2):143-155.
[7]Parente R,Trifir E,Cuozzo F,et al.Cyclooxygenase-2 is induced by p38 MAPK and promotes cell survival[J].Oncol Rep,2013,29(5):1999-2004.
[8]Tormos AM,Arduini A,Talens-Visconti R,et al.Liverspecific p38αdeficiency causes reduced cell growth and cytokinesis failure during chronic biliary cirrhosis in mice[J].Hepatology,2012 Nov 29.doi:10.1002/hep.26174.
[9]Guo YY,Wang WD,Wang J,et al.Receptor for activated C kinase 1 promotes hepatocellular carcinoma by enhancing mitogen-activated protein kinase kinase 7activity[J].Hepatology,2013,57(1):140-151.
[10]Sun KK,Ji C,Li X,et al.Overexpression of high mobility group protein B1 correlates with the proliferation and metastasis of lung adenocarcinoma cells[J].Mol Med Rep,2013,7(5):1678-1682.
[11]Zhang S,Nie S,Huang D,et al.Polysaccharide from ganoderma atrum evokes antitumor activity via toll-like receptor 4-mediated NF-κB and mitogen-activated protein kinase signaling pathways[J].J Agric Food Chem,2013,61(15):3676-3682.
[12]陈凯,孙慧燕,牟心红,等.TGF-p/smad及TGF-B/MAPK介导肿瘤细胞凋亡的机制[J]武警后勤学院学报(医学版),2012,21(2):144-152.
[13]Bodur C,Kutuk O,Karsli-Uzunbas G,et al.Pramanicin analog induces apoptosis in human colon cancer cells:critical roles for Bcl-2,Bim,and p38 MAPK signaling[J].PLoS One,2013,8(2):e56369.doi:10.1371/journal.pone.0056369.
[14]Azijli K,Yuvaraj S,van Roosmalen I,et al.MAPK p38and JNK have opposing activities on TRAIL-induced apoptosis activation in NSCLC H460 cells that involves RIP1 and caspase-8 and is mediated by Mcl-1[J].Apoptosis,2013,18(7):851-860.
[15]李琦,刘宁宁,范忠泽,等.p38丝裂原活化蛋白激酶信号转导对肿瘤细胞凋亡的调控[J].国际肿瘤学杂志,2009,36(3):163-166.
[16]Tan N,Wong M,Nannini MA,et al.Bcl-2/Bcl-xL inhibition increases the efficacy of mek inhibition alone and in combination with p13 kinase inhibition in lung and pancreatic tumor models[J].Mol Cancer Ther,2013 Mar 8,doi:10.1158/1535-7163.MCT-12-0949.
[17]李文海,梁军,王春梅,等.水飞蓟素可通过MAPK信号传导通路促进肺腺癌A549细胞凋亡[J].第四军医大学报,2008,29(5):461-464.
[18]杨泽松,牟君,陈建斌,等.苦参碱通过MAPK信号转导通路促进U937细胞凋亡[J].中国中药杂志,2009,34(12):1553-1556.
[19]陈红芳,邓华瑜.MAPK信号转导通路与肿瘤侵袭转移[J].国际检验医学杂志,2007,28(6):551-553.
[20]毛华,袁爱力,趁墼羞,等.p38MAPK信号通路影响血管内皮细胞生长因子诱导肝癌细胞超微结构变化[J].世界华人消化杂志,2000,8(5):536-538.
[21]毛华,黄纯炽,赵敏芳,等.p38MAPK信号传导通路调控VEGF诱导肝癌细胞黏附作用[J].世界华人消化杂志,2006,14(8):778-783.
[22]张曦倩,庞战军,陈士岭,等.p38MAPK抑制剂SB203580抑制人绒癌JAR细胞的体外侵袭作用[J].实用肿瘤杂志,2003,18(2):95-97.
[23]Kwon CH,Moon HJ,Park HJ,et al.S100A8 and S100A9promotes invasion and migration through p38 mitogenactivated protein kinase-dependent NF-κB activation in gastric cancer cells[J].Mol Cells,2013,35(3):226-234.
[24]Wang XF,Zhou QM,Du J,et al.Baicalin suppresses migration,invasion and metastasis of breast cancer via p38MAPK signaling pathway[J].Anticancer Agents Med Chem,2013 Jan 24,doi:10.1158/1535-7163.MCT-12-0949.
[25]Liu H,Wang Z,Li Y,et al.Simvastatin prevents proliferation and bone metastases of lung adenocarcinoma in vitro and in vivo[J].Neoplasma,2013,60(3):240-246.
[26]Deng W,Sui H,Wang Q,et al.A Chinese herbal formula,Yi-Qi-Fu-Sheng,inhibits migration/invasion of colorectal cancer by down-regulating MMP-2/9 via inhibiting the activation of ERK/MAPK signaling pathways[J].BMC Complement Altern Med,2013,13(1):65.
[27]万芳,钟刚,何福仙,等.ERK/MAPK信号通路激活与乳腺癌细胞浸润性生长的关系[J].医学研究生报,2004,17(6):490-492.
[28]Drigotas M,Affolter A,Mann WJ,et al.Reactive oxygen species activation of MAPK pathway results in VEGF upregulation as an undesired irradiation response[J].J Oral Pathol Med,2013 Mar 11.doi:10.1111/jop.12056.
[29]Tate CM,Blosser W,Wyss L,et al.LY2228820dimesylate,a selective inhibitor of p38 mitogen-activated protein kinase,reduces angiogenic endothelial cord formation in vitro and in vivo[J].J Biol Chem,2013,288(9):6743-6753.
[30]Lee SH,Lee J,Jung MH,et al.Glyceollins,a novel class of soy phytoalexins,inhibit angiogenesis by blocking the VEGF and bFGF signaling pathways[J].Mol Nutr Food Res,2013,57(2):225-234.
[31]Culig Z.Interleukin-6 as a therapy target in oral squamous carcinoma[J].Expert Opin Ther Targets,2013,17(1):53-59.
基本信息:
DOI：10.13267/j.cnki.syzlzz.2013.05.028
中图分类号:R730.231
引用信息:
[1]崔婷婷,席淑华.MAPK信号传导通路与肿瘤的发生[J].实用肿瘤杂志,2013,28(05):550-552.DOI:10.13267/j.cnki.syzlzz.2013.05.028.
基金信息:
国家自然科学基金(81072244)
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