金芳玲,胡祖良,马海锋,杜锦跃

• 1:东阳市人民医院放疗科

摘要(Abstract)：

目的探讨新辅助放化疗联合手术治疗局部晚期食管癌较单纯手术治疗能否改善总生存率。方法Ⅱa～Ⅲ期食管癌患者60例,随机分成新辅助放化疗联合手术组及单纯手术治疗组,每组30例。化疗使用PF方案,DDP 75 mg/(m2.d),d1,5-FU 500 mg/(m2.d),d1-5持续滴注,第1次化疗与第1次放疗同时实施,每3周1个疗程,放疗期间共2个疗程。放化疗结束后2-4周行食管癌根治术。放疗剂量PTV靶区给予每次2.0 Gy,5次/周,总剂量50 Gy。结果给予新辅助放化疗联合手术组患者必要的对症支持治疗,患者均能够完成同期放化疗。新辅助放化疗联合手术组并发症多于单纯手术组,但两组比较差异无统计学意义。1、2、3年生存率新辅助放化疗联合手术组分别为83.3%、65.3%、42.8%,单纯手术组分别为80.0%、41.6%、25.0%(χ2=3.992,P=0.046)。结论新辅助放化疗联合手术治疗可以改善局部晚期食管癌的总生存率,且不明显增加术后并发症,值得临床推广应用。

关键词(KeyWords)： 食管肿瘤/外科学;食管肿瘤/药物疗法;化学疗法,辅助;手术后并发症;临床对照试验

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 金芳玲,胡祖良,马海锋,杜锦跃

DOI: 10.13267/j.cnki.syzlzz.2011.05.028

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