乳腺大汗腺癌临床病理及预后分析(附2例报道及文献复习)Clinicopathologic features and prognosis of breast apocrine carcinoma(Two cases report)
胡祖健,徐海滨,何俊玲,苏昆仑,杨欧欧,杨文伟
摘要(Abstract):
目的探讨乳腺大汗腺癌的临床病理特征、诊断及预后。方法应用免疫组织化学方法检测乳腺大汗腺癌患者ER、AR和GCDFP-15的表达,同时复习国内外文献。结果乳腺大汗腺癌的临床表现如年龄分布、肿瘤部位以及肉眼形态和影像学特点与非大汗腺型乳腺癌无明显差别。乳腺大汗腺癌病理表现为肿瘤细胞具有大汗腺分化,免疫组织化学表现为较高的ER、PR阴性率和AR阳性。结论乳腺大汗腺癌是一种罕见的乳腺肿瘤,无特异性的临床特征,有特征性的病理改变,较好的预后。
关键词(KeyWords): 乳腺肿瘤/病理学;汗腺肿瘤;预后;免疫组织化学
基金项目(Foundation):
作者(Author): 胡祖健,徐海滨,何俊玲,苏昆仑,杨欧欧,杨文伟
DOI: 10.13267/j.cnki.syzlzz.2011.05.006
参考文献(References):
- [1]张艳华,李洁冰,王雷.乳腺大汗腺癌超声表现1例[J].中华超声影像学杂志,2005,14(11):846.
- [2]D'Amore ES,Terrier-Lacombe MJ,Travagli JP,et al.Invasive apocrine carcinoma of the breast:a long-termfollow-up study of 34 cases[J].Breast Cancer Res Treat,1988,12(1):37-44.
- [3]Rosen PP.Rosen's breast pathology[M].ed 2.NewYork:Lippincott Williams&Wilkins,2001:483-494.
- [4]Tanaka K,Imoto S,Wada N,et al.Invasive apocrinecarcinoma of the breast:clinicopathologic features of 57patients[J].Breast J2,0081,4(2):164-168.
- [5]邵牧民,孟刚,龚西騟.乳腺大汗腺癌的形态学与免疫表型特征[J].临床与实验病理学杂志,2005,21(1):14-19.
- [6]Matsuo K,Fukutomi T,Tsuda H,et al.Apocrinecarcinoma of the breast:clinicopathological analysis andhistological subclassification of 12 cases[J].BreastCancer,19985,(3):279-284.
- [7]Bratthauer GL,Lininger RA,Man YG,et al.Androgenand estrogen receptor mRNA status in apocrinecarcinomas[J].Diagn Mol Pathol,2002,11(2):113-118.